Article

Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in osteosarcoma

2020-11-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Osteosarcoma (OSA) is an aggressive malignancy predominantly affecting children and young-adults. Genetic analysis has characterized very few recurrent mutations in OSA, and an improved understanding of interpatient tumor heterogeneity is needed for clinical management. <h4>Methods</h4> We analyzed genome-wide DNA methylation in primary OSA tumors from the NCI Therapeutically...

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Literature Corpus work: 9c0d9f50-5ed1-50e0-a5ac-440578119894
DOI: 10.1101/2020.11.26.20238584

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