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Article

Hypoxia/Ischemia-Induced Rod Microglia Phenotype in CA1 Hippocampal Slices.

International journal of molecular sciences - 26 Jan 2022

Lana Daniele, Gerace Elisabetta, Magni Giada, Cialdai Francesca, Monici Monica, Mannaioni Guido, Giovannini Maria Grazia

Abstract excerpt

The complexity of microglia phenotypes and their related functions compels the continuous study of microglia in diseases animal models. We demonstrated that oxygen-glucose deprivation (OGD) induced rapid, time- and space-dependent phenotypic microglia modifications in CA1 stratum pyramidalis (SP) and stratum radiatum (SR) of rat organotypic hippocampal slices as well as the degeneration of pyramidal neurons,...

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Identifiers

PMID: 35163344
DOI: 10.3390/ijms23031422
PMCID: PMC8836225

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