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Article

A potential gliovascular mechanism for microglial activation: differential phenotypic switching of microglia by endothelium versus astrocytes.

Journal of neuroinflammation - 15 May 2018

Xing Changhong, Li Wenlu, Deng Wenjun, Ning MingMing, Lo Eng H

Abstract excerpt

BACKGROUND: Activation of microglia can result in phenotypic and functional diversity. However, the pathways that trigger different states of microglial activation remain to be fully understood. Here, we hypothesized that after injury, astrocytes and endothelium may contribute to a gliovascular switch for microglial activation. METHODS: Astrocytes or cerebral endothelial cells were subjected to oxygen glucose...

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Identifiers

PMID: 29764475
DOI: 10.1186/s12974-018-1189-2
PMCID: PMC5952884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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