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Article

Neonatal hypoxia-ischemia in rat elicits a region-specific neurotrophic response in SVZ microglia.

Journal of neuroinflammation - 18 Jan 2020

Fisch Urs, Brégère Catherine, Geier Florian, Chicha Laurie, Guzman Raphael

Abstract excerpt

BACKGROUND: Recent findings describe microglia as modulators of neurogenesis in the subventricular zone (SVZ). SVZ microglia in the adult rat are thought to adopt a neurotrophic phenotype after ischemic stroke. Early postnatal microglia are endogenously activated and may therefore exhibit an increased sensitivity to neonatal hypoxia-ischemia (HI). The goal of this study was to investigate the impact of...

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Identifiers

PMID: 31954397
DOI: 10.1186/s12974-020-1706-y
PMCID: PMC6969423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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