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CNOT6: A Novel Regulator of DNA Mismatch Repair

2 Feb 2022

Abstract excerpt

DNA mismatch repair (MMR) is a highly conserved pathway that corrects both base-base mispairs and insertion-deletion loops (IDLs) generated during DNA replication. Defects in MMR have been linked to carcinogenesis and drug resistance. However, the regulation of MMR is poorly understood. Interestingly, CNOT6 is one of four deadenylase subunits in the conserved CCR4-NOT complex and it targets poly(A) tails of mRNAs...

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PMID: 35159331
DOI: 10.3390/cells11030521

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