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Article

Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex

20 Jul 2012

Abstract excerpt

The Ccr4-Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease-exonuclease-phosphatase)-type...

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PMID: 22817755
DOI: 10.1042/bst20120074

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