Article
KDM6A-SND1 interaction maintains genomic stability by protecting the nascent DNA and contributes to cancer chemoresistance.
Nucleic acids research - 22 Jul 2024
Wu Jian, Jiang Yixin, Zhang Qin, Mao Xiaobing, Wu Tong, Hao Mengqiu, Zhang Su, Meng Yang, Wan Xiaowen, Qiu Lei, Han Junhong
Abstract excerpt
Genomic instability is one of the hallmarks of cancer. While loss of histone demethylase KDM6A increases the risk of tumorigenesis, its specific role in maintaining genomic stability remains poorly understood. Here, we propose a mechanism in which KDM6A maintains genomic stability independently on its demethylase activity. This occurs through its interaction with SND1, resulting in the establishment of a...
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