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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

10 Jul 2018

Abstract excerpt

Cells respond to cytotoxic DNA double-strand breaks by recruiting repair proteins to the damaged site. Phosphorylation of the histone variant H2AX at S139 and Y142 modulate its interaction with downstream DNA repair proteins and their recruitment to DNA lesions. Here we report ATM-dependent ZNF506 localization to the lesion through MDC1 following DNA damage. ZNF506, in turn, recruits the protein phosphatase EYA,...

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PMID: 30013081
DOI: 10.1038/s41467-018-05161-0

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