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Article

Effects of Tumor Mutational Burden and Gene Alterations Associated with Radiation Response on Outcomes of Postoperative Radiation Therapy in Non-Small Cell Lung Cancer.

International journal of radiation oncology, biology, physics - 1 Jun 2022

Shaverdian Narek, Shepherd Annemarie F, Li Xingzhe, Offin Michael, Lengel Harry B, Gelblum Daphna Y, Wu Abraham J, Simone Charles B, Rimner Andreas, Jones David R, Chaft Jamie E, Riaz Nadeem, Gomez Daniel R

Abstract excerpt

PURPOSE: Postoperative radiation therapy (PORT) in resected non-small cell lung cancer (NSCLC) improves locoregional outcomes, but recent randomized data do not support its unselected use. We assessed if tumor mutational burden (TMB) and mutations in genes associated with radiation sensitivity can select patients for PORT. METHODS AND MATERIALS: Patients with resected NSCLC treated with and without PORT who...

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Identifiers

PMID: 35157996
DOI: 10.1016/j.ijrobp.2022.02.014
PMCID: PMC9976944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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