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Article

Correlation of alterations in the KEAP1 / CUL3 / NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma

3 Jun 2021

Abstract excerpt

Abstract Objectives Patients with laryngeal squamous cell carcinoma (LSCC) often fail radiation therapy (RT), when received as monotherapy or in combination with other treatment modalities. Mechanisms for RT failure are poorly understood. We hypothesized that tumors failing RT would have increased rates of somatic mutations in genes associated with radiation resistance, particularly in genes associated with the...

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PMID: 34401494
DOI: 10.1002/lio2.588

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