Article
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition.
Cancer discovery - 1 Dec 2020
Binkley Michael S, Jeon Young-Jun, Nesselbush Monica, Moding Everett J, Nabet Barzin Y, Almanza Diego, Kunder Christian, Stehr Henning, Yoo Christopher H, Rhee Siyeon, Xiang Michael, Chabon Jacob J, Hamilton Emily, Kurtz David M, Gojenola Linda, Owen Susie Grant, Ko Ryan B, Shin June Ho, Maxim Peter G, Lui Natalie S, Backhus Leah M, Berry Mark F, Shrager Joseph B, Ramchandran Kavitha J, Padda Sukhmani K, Das Millie, Neal Joel W, Wakelee Heather A, Alizadeh Ash A, Loo Billy W, Diehn Maximilian
Abstract excerpt
Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations of mutations with outcome. Here, we analyze 232 consecutive patients with localized NSCLC and demonstrate that KEAP1 and NFE2L2 mutations are predictive of high rates of local recurrence (LR) after radiotherapy but not surgery. Half of LRs occurred in tumors with KEAP1/NFE2L2 mutations,...
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