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Article

PARP-1 genetic polymorphism associated with radiation sensitivity of non-small cell lung cancer.

Pathology oncology research : POR - 1 Jan 2022

Wang Hetong, Xie Haitao, Wang Shuying, Zhao Jiaying, Gao Ya, Chen Jun, Zhao Yuxia, Guo Genyan

Abstract excerpt

About 70% of non-small cell lung cancer (NSCLC) patients require radiotherapy. However, due to the difference in radiation sensitivity, the treatment outcome may differ for the same pathology and choice of treatment. Poly (ADP-ribose) polymerase 1 (PARP-1) is a key gene responsible for DNA repair and is involved in base excision repair as well as repair of single strand break induced by ionizing radiation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36590386
DOI: 10.3389/pore.2022.1610751
PMCID: PMC9795517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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