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Article

Use a survival model to correlate single-nucleotide polymorphisms of DNA repair genes with radiation dose-response in patients with non-small cell lung cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Oct 2015

Jin Jian-Yue, Wang Weili, Ten Haken Randall K, Chen Jie, Bi Nan, Sadek Ramses, Zhang Hong, Lawrence Theodore S, Kong Feng-Ming Spring

Abstract excerpt

PURPOSE: This study utilizes a survival model and clinical data with various radiation doses from prospective trials to determine radiation dose-response parameters, such as radiosensitivity, and identify single-nucleotide-polymorphism (SNP) biomarkers that can potentially predict the dose response and guide personalized radiotherapy. METHODS: The study included 92 consecutive stage-III NSCLC patients with doses...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Radiation

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Source

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Identifiers

PMID: 26253951
DOI: 10.1016/j.radonc.2015.07.024
PMCID: PMC4702521

Genes

ERCC1
ERCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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