Article
Effects of EGFR driver mutations on pathologic regression in resectable locally advanced non-small cell lung cancer treated with neoadjuvant chemoradiation and completion surgery.
The British journal of radiology - 1 Dec 2023
Appel Sarit, Bar Jair, Saad Akram, Marom Edith Michelle, Urban Damien, Onn Amir, Gantz-Sorotsky Hadas, Kremer Ran Yosef, Ben-Nun Alon, Perelman Marina, Ofek Efrat, Yacobi Rinat, Daher Sameh, Rasco Adi, Symon Zvi, Lawrence Yaacov Richard, Goldstein Jeffrey
Abstract excerpt
OBJECTIVE: We hypothesized that driver mutations in epidermal growth factor receptor (EGFR) are associated with decreased pathologic response to neoadjuvant chemoradiation (NA-ChRT) in locally advanced non-small cell lung cancer (LA-NSCLC). METHODS: Patients with Stage IIB-IIIA NSCLC treated with NA-ChRT, completion surgery, and underwent molecular profile testing were identified in a lung cancer database....
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