Article
Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array.
Neoplasia (New York, N.Y.) - 1 Jul 2008
Toma Marieta I, Grosser Marianne, Herr Alexander, Aust Daniela E, Meye Axel, Hoefling Christian, Fuessel Susanne, Wuttig Daniela, Wirth Manfred P, Baretton Gustavo B
Abstract excerpt
Genetic aberrations are crucial in renal tumor progression. In this study, we describe loss of heterozygosity (LOH) and DNA-copy number abnormalities in clear cell renal cell carcinoma (cc-RCC) discovered by genome-wide single nucleotide polymorphism (SNP) arrays. Genomic DNA from tumor and normal tissue of 22 human cc-RCCs was analyzed on the Affymetrix GeneChip Human Mapping 10K Array. The array data were...
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