Predicting the Likelihood of Carrying a BRCA1 or BRCA2 Mutation in Asian Patients With Breast Cancer.

doi:10.1200/JCO.21.01647

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Article

Predicting the Likelihood of Carrying a BRCA1 or BRCA2 Mutation in Asian Patients With Breast Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2022

Ang Boon Hong, Ho Weang Kee, Wijaya Eldarina, Kwan Pui Yoke, Ng Pei Sze, Yoon Sook Yee, Hasan Siti Norhidayu, Lim Joanna M C, Hassan Tiara, Tai Mei-Chee, Allen Jamie, Lee Andrew, Taib Nur Aishah Mohd, Yip Cheng Har, Hartman Mikael, Lim Swee Ho, Tan Ern Yu, Tan Benita K T, Tan Su-Ming, Tan Veronique K M, Ho Peh Joo, Khng Alexis J, Dunning Alison M, Li Jingmei, Easton Douglas F, Antoniou Antonis C, Teo Soo Hwang

Abstract excerpt

PURPOSE: With the development of poly (ADP-ribose) polymerase inhibitors for treatment of patients with cancer with an altered BRCA1 or BRCA2 gene, there is an urgent need to ensure that there are appropriate strategies for identifying mutation carriers while balancing the increased demand for and cost of cancer genetics services. To date, the majority of mutation prediction tools have been developed in women of...

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Identifiers

PMID: 35143328
DOI: 10.1200/JCO.21.01647
PMCID: PMC7614269

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