BRCA Testing in Asian Patients with Ovarian Cancer: Standard Clinical Practice or Mutation Prediction Model?

doi:10.1158/1055-9965.EPI-25-2008

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Article

BRCA Testing in Asian Patients with Ovarian Cancer: Standard Clinical Practice or Mutation Prediction Model?

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2026

Ang Boon Hong, Yoon Sook-Yee, Lim Joanna, Hassan Nur Tiara, Tai Mei-Chee, Wong Zhi Lei, Chow Jo Yi, Lee Xin Wen, Thong Meow-Keong, Ch'ng Gaik-Siew, Omar Jamil, Yong Chee-Meng, Aliyas Ismail, Abdul Malik Rozita, Subramaniam Suguna, Sim Wee-Wee, Lim Chun Sen, Lee Saw-Joo, Lim Keng-Joo, Shafiee Mohamad Nasir, Ismail Fuad, Ismail Mohd Pazudin, Kumarasamy Suresh, Low John Seng Hooi, Ahmad Mustafa Ahmad Muzamir, Makanjang Mary J, Tayib Shahila, Cheah Nellie L C, Fong Chee-Kin, Ho Kean-Fatt, Deniel Azura, Ang Soo-Fan, Ahmad Badruddin Ahmad Radzi, Tho Lye-Mun, Woo Yin Ling, Ho Weang-Kee, Teo Soo-Hwang

Abstract excerpt

BACKGROUND: Germline BRCA1/2 testing is recommended for all patients with ovarian cancer, as identifying pathogenic variants (PV) informs treatment and enables family cascade testing. However, in resource-limited settings, high testing costs often limit feasibility. An alternative approach is to use predictive models to prioritize patients at risk, optimizing resource allocation. Existing models are largely...

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PMID: 42013351
DOI: 10.1158/1055-9965.EPI-25-2008
PMCID: PMC7619263

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BRCA1
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