Article
The earliest events in BRAF-mutant colorectal cancer: exome sequencing of sessile serrated lesions with a tiny focus dysplasia or cancer reveals recurring mutations in two distinct progression pathways.
The Journal of pathology - 1 Jun 2022
Bleijenberg Arne Gc, IJspeert Joep Eg, Mulder Jos Bg, Drillenburg Paul, Stel Herbert V, Lodder Elisabeth M, Carvalho Beatriz, Jansen Jade, Meijer Gerrit, van Eeden Susanne, Dekker Evelien, van Noesel Carel Jm
Abstract excerpt
Around 15-30% of colorectal cancers (CRC) develop from sessile serrated lesions (SSLs). After many years of indolent growth, SSLs can develop dysplasia and rapidly progress to CRC through events that are only partially understood. We studied molecular events at the very early stages of progression of SSLs via the MLH1-proficient and deficient pathways to CRC. We collected a cohort of rare SSLs with a small focus...
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