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Article

Convergent genetic and expression data implicate immunity in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2015

Abstract excerpt

BACKGROUND: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. METHODS: The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression...

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Identifiers

PMID: 25533204
DOI: 10.1016/j.jalz.2014.05.1757
PMCID: PMC4672734

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