Article
Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease.
JCI insight - 8 Feb 2022
Yu Mengyao, Tcheandjieu Catherine, Georges Adrien, Xiao Ke, Tejeda Helio, Dina Christian, Le Tourneau Thierry, Fiterau Madalina, Judy Renae, Tsao Noah L, Amgalan Dulguun, Munger Chad J, Engreitz Jesse M, Damrauer Scott M, Bouatia-Naji Nabila, Priest James R
Abstract excerpt
The fibrous annulus of the mitral valve plays an important role in valvular function and cardiac physiology, while normal variation in the size of cardiovascular anatomy may share a genetic link with common and rare disease. We derived automated estimates of mitral valve annular diameter in the 4-chamber view from 32,220 MRI images from the UK Biobank at ventricular systole and diastole as the basis for GWAS....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.