Article
Cardiac Imaging of Aortic Valve Area From 34 287 UK Biobank Participants Reveals Novel Genetic Associations and Shared Genetic Comorbidity With Multiple Disease Phenotypes.
Circulation. Genomic and precision medicine - 1 Dec 2020
Córdova-Palomera Aldo, Tcheandjieu Catherine, Fries Jason A, Varma Paroma, Chen Vincent S, Fiterau Madalina, Xiao Ke, Tejeda Heliodoro, Keavney Bernard D, Cordell Heather J, Tanigawa Yosuke, Venkataraman Guhan, Rivas Manuel A, Ré Christopher, Ashley Euan, Priest James R
Abstract excerpt
BACKGROUND: The aortic valve is an important determinant of cardiovascular physiology and anatomic location of common human diseases. METHODS: From a sample of 34 287 white British ancestry participants, we estimated functional aortic valve area by planimetry from prospectively obtained cardiac magnetic resonance imaging sequences of the aortic valve. Aortic valve area measurements were submitted to genome-wide...
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