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Article

Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci.

Circulation research - 5 Mar 2021

Kyryachenko Sergiy, Georges Adrien, Yu Mengyao, Barrandou Takiy, Guo Lilong, Bruneval Patrick, Rubio Tony, Gronwald Judith, Baraki Hassina, Kutschka Ingo, Aras Kedar K, Efimov Igor R, Norris Russel A, Voigt Niels, Bouatia-Naji Nabila

Abstract excerpt

RATIONALE: Mitral valve prolapse (MVP) is a common valvopathy that leads to mitral insufficiency, heart failure, and sudden death. Functional genomic studies in mitral valves are needed to better characterize MVP-associated variants and target genes. OBJECTIVE: To establish the chromatin accessibility profiles and assess functionality of variants and narrow down target genes at MVP loci. METHODS AND RESULTS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33508947
DOI: 10.1161/CIRCRESAHA.120.317581
PMCID: PMC8316483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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