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ARID1A loss-of-function induces CpG island methylator phenotype.

Cancer letters - 28 Apr 2022

Yamada Harumi, Takeshima Hideyuki, Fujiki Ryoji, Yamashita Satoshi, Sekine Shigeki, Ando Takayuki, Hattori Naoko, Okabe Atsushi, Yoshikawa Takaki, Obama Kazutaka, Katai Hitoshi, Kaneda Atsushi, Ushijima Toshikazu

Abstract excerpt

The CpG island methylator phenotype (CIMP) is associated with prognosis and drug sensitivity in multiple cancer types. In gastric cancer, the CIMP is closely associated with Epstein-Barr virus (EBV) infection and AT-rich interactive domain 1A (ARID1A) mutations, a component of the SWI/SNF chromatin remodeling complex. However, the involvement of SWI/SNF defects in CIMP induction has been unclear. In this study,...

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PMID: 35131383
DOI: 10.1016/j.canlet.2022.215587

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