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ARID1A Mutations in Gastric Cancer: A Review with Focus on Clinicopathological Features, Molecular Background and Diagnostic Interpretation

30 May 2024

Abstract excerpt

AT-rich interaction domain 1 (ARID1A) is a pivotal gene with a significant role in gastrointestinal tumors which encodes a protein referred to as BAF250a or SMARCF1, an integral component of the SWI/SNF (SWItch/sucrose non-fermentable) chromatin remodeling complex. This complex is instrumental in regulating gene expression by modifying the structure of chromatin to affect the accessibility of DNA. Mutations in...

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Cancer Mechanisms and Therapy
Chromatin Remodeling and Cancer
Peptidase Inhibition and Analysis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38893181
DOI: 10.3390/cancers16112062

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