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The effects of ARID1A mutation in gastric cancer and its significance for treatment

26 Nov 2023

Abstract excerpt

Gastric cancer (GC) has emerged as a significant issue in public health all worldwide as a result of its high mortality rate and dismal prognosis. AT-rich interactive domain 1 A (ARID1A) is a vital component of the switch/sucrose-non-fermentable (SWI/SNF) chromatin remodeling complex, and ARID1A mutations occur in various tumors, leading to protein loss and decreased expression; it then affects the tumor...

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PMID: 38008753
DOI: 10.1186/s12935-023-03154-8

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