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Article

Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes.

Diabetologia - 1 May 2022

Walker Venexia M, Vujkovic Marijana, Carter Alice R, Davies Neil M, Udler Miriam S, Levin Michael G, Davey Smith George, Voight Benjamin F, Gaunt Tom R, Damrauer Scott M

Abstract excerpt

AIMS/HYPOTHESIS: Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral artery disease from those mediated by type 2 diabetes. METHODS: Our main analysis was a two-step Mendelian randomisation for mediation to quantify the extent to which the associations observed...

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Source

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Identifiers

PMID: 35129650
DOI: 10.1007/s00125-022-05653-1
PMCID: PMC8960614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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