Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic support for the causal role of insulin in coronary heart disease.

Diabetologia - 1 Nov 2016

Tikkanen Emmi, Pirinen Matti, Sarin Antti-Pekka, Havulinna Aki S, Männistö Satu, Saltevo Juha, Lokki Marja-Liisa, Sinisalo Juha, Lundqvist Annamari, Jula Antti, Salomaa Veikko, Ripatti Samuli

Abstract excerpt

AIMS/HYPOTHESIS: Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables. METHODS: Based on published genome-wide association studies (GWASs),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Disease

Share to Genome-Wide Association Study

Share to Insulin

Share to Insulin Resistance

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Identifiers

PMID: 27561896
DOI: 10.1007/s00125-016-4081-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic support for the causal role of insulin in coronary heart disease.PMID 27561896Read ↗

Dissecting the Genetic Link Between Insulin Resistance and Coronary Heart Disease: A Multi-Trait GWAS and Proteomic-Metabolomic Mediation AnalysisSemantic proximity Read ↗

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study.Semantic proximity Read ↗

Causal Associations Between Age at Diagnosis of Diabetes and Cardiovascular Outcomes: A Mendelian Randomization Study.Semantic proximity Read ↗

Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signallingSemantic proximity Read ↗

Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization studySemantic proximity Read ↗

Individual or familial diabetes in relation to eight cardiovascular diseases: A two-sample Mendelian randomization study.Semantic proximity Read ↗

Birth Weight, Cardiometabolic Factors, and Coronary Heart Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

Linkage analysis of factors underlying insulin resistance: Strong Heart Family Study.Semantic proximity Read ↗

Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.Semantic proximity Read ↗

Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK BiobankSemantic proximity Read ↗

Evidence for joint action of genes on diabetes status and CVD risk factors in American Indians: the strong heart family study.Semantic proximity Read ↗

Insulin resistance: an atherothrombotic syndrome. The Leeds family study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.