Article

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study

2022-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 diabetes (T2D) and coronary artery disease (CAD) both have known genetic determinants, but the mechanisms through which their associated genetic variants lead to disease onset remain poorly understood. Here, we used large-scale metabolomics data to directly compare the metabolic features of genetic liability to T2D and to CAD. We performed two-sample reverse Mendelian randomization (MR) to...

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Literature Corpus work: 0b8a73cb-c1b4-5fda-9c55-7b3d5afc9adc
DOI: 10.1101/2022.04.13.22273833

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