Article
Competing analytical strategies of combining associated SNPs for estimating genetic risks.
Journal of genetics - 1 Jan 2022
Majumdar Arunabha, Ghosh Saurabh
Abstract excerpt
In genomewide association study (GWAS) of a complex phenotype, a large number of variants, many with small effect sizes, are found to contribute to the variability of the phenotype. Subsequent to the identification of such variants in a GWAS, it is of interest to estimate the risk jointly conferred by the variants. We propose three different strategies of combining the risk SNPs to calculate an allele dosage...
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