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[Genetic risk assessment of the joint effect of several genes: Critical appraisal].

Genetika - 1 Jul 2016

Rubanovich A V, Khromov-Borisov N N

Abstract excerpt

When assessing the combined action of genes on the quantitative or qualitative phenotype we encounter a phenomenon that could be named the “paradox of the risk score summation.” It arises when the search of risk allele and assessment of their combined action are performed with the same single dataset. Too often such methodological error occurs when calculating the so called genetic risk score (GRS), which refers...

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PMID: 29368872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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