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Article

Weighted Score Tests Implementing Model-Averaging Schemes in Detection of Rare Variants in Case-Control Studies.

PloS one - 1 Jan 2015

Coombes Brandon, Basu Saonli, Guha Sharmistha, Schork Nicholas

Abstract excerpt

Multi-locus effect modeling is a powerful approach for detection of genes influencing a complex disease. Especially for rare variants, we need to analyze multiple variants together to achieve adequate power for detection. In this paper, we propose several parsimonious branching model techniques to assess the joint effect of a group of rare variants in a case-control study. These models implement a data reduction...

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Identifiers

PMID: 26436424
DOI: 10.1371/journal.pone.0139355
PMCID: PMC4593572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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