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Article

Comparison of adaptive multiple phenotype association tests using summary statistics in genome-wide association studies.

Human molecular genetics - 9 Jul 2021

Sitlani Colleen M, Baldassari Antoine R, Highland Heather M, Hodonsky Chani J, McKnight Barbara, Avery Christy L

Abstract excerpt

Genome-wide association studies have been successful mapping loci for individual phenotypes, but few studies have comprehensively interrogated evidence of shared genetic effects across multiple phenotypes simultaneously. Statistical methods have been proposed for analyzing multiple phenotypes using summary statistics, which enables studies of shared genetic effects while avoiding challenges associated with...

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PMID: 33949650
DOI: 10.1093/hmg/ddab126
PMCID: PMC8283209

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