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Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4

30 Dec 2021

Abstract excerpt

BACKGROUND AND AIMS: High glucose and its byproducts are important factors causing dysfunction of endothelial cells. Autophagy is critical for endothelial cellular homeostasis. However, the specific molecular mechanism of how autophagy is regulated in endothelial cells under high-glucose condition remains unknown. We aim to explore the role Sirt6 plays in regulating autophagy in AGE-treated endothelial cells and...

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PMID: 35123854
DOI: 10.1016/j.numecd.2021.12.020

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