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Article

TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.

Aging cell - 1 Dec 2018

Huy Hangsak, Song Hae Young, Kim Mi Jeong, Kim Won Sam, Kim Dong Oh, Byun Jae-Eun, Lee Jungwoon, Park Young-Jun, Kim Tae-Don, Yoon Suk Ran, Choi Eun-Ji, Lee Chul-Ho, Noh Ji-Yoon, Jung Haiyoung, Choi Inpyo

Abstract excerpt

Aging is associated with an inevitable and universal loss of cell homeostasis and restricts an organism's lifespan by an increased susceptibility to diseases and tissue degeneration. The glucose uptake associated with producing energy for cell survival is one of the major causes of ROS production under physiological conditions. However, the overall mechanisms by which glucose uptake results in cellular senescence...

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Share to Cellular Senescence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 30168649
DOI: 10.1111/acel.12836
PMCID: PMC6260918

Genes

TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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