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Article

SIRT6 protects against endothelial dysfunction and atherosclerosis in mice

30 May 2016

Abstract excerpt

SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE(-/-) mice and human patients. However, the role of SIRT6 in regulating vascular endothelial function and atherosclerosis is not well understood. Here we show that SIRT6 protects against...

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Identifiers

PMID: 27249230
DOI: 10.18632/aging.100975

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