Article
The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.
Nature cancer - 1 Apr 2021
Liu Jiang, Lao Liyan, Chen Jianing, Li Jiang, Zeng Wenfeng, Zhu Xiaofeng, Li Jiaqian, Chen Xueman, Yang Linbin, Xing Yue, Chen Fei, Huang Di, Zhang Xiaoqian, Wei Wei, Gong Chang, Huang Shuya, Yu Zhigang, Li Zhihua, Yang Linhan, Liu Jinping, Liu Xiaozhen, Zheng Qinghui, Meng Xuli, Liang Jing, Sun Luyang, Zeng Musheng, Li Mengfeng, Liu Qiang, Su Shicheng, Song Erwei
Abstract excerpt
Although chemotherapy can stimulate antitumor immunity by inducing interferon (IFN) response, the functional role of tumor-associated macrophages in this scenario remains unclear. Here, we found that IFN-activated proinflammatory macrophages after neoadjuvant chemotherapy enhanced antitumor immunity but promoted cancer chemoresistance. Mechanistically, IFN induced expression of cytoplasmic long noncoding RNA...
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