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Article

Epigenetic state determines inflammatory sensing in neuroblastoma

4 Feb 2022

Abstract excerpt

Immunotherapy has revolutionized cancer treatment, but many cancers are not impacted by currently available immunotherapeutic strategies. Here, we investigated inflammatory signaling pathways in neuroblastoma, a classically "cold" pediatric cancer. By testing the functional response of a panel of 20 diverse neuroblastoma cell lines to three different inflammatory stimuli, we found that all cell lines have intact...

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PMID: 35121657
DOI: 10.1073/pnas.2102358119

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