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Article

Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study.

Kidney international - 1 Apr 2022

Rhee Eugene P, Surapaneni Aditya, Zheng Zihe, Zhou Linda, Dutta Diptavo, Arking Dan E, Zhang Jingning, Duong ThuyVy, Chatterjee Nilanjan, Luo Shengyuan, Schlosser Pascal, Mehta Rupal, Waikar Sushrut S, Saraf Santosh L, Kelly Tanika N, Hamm Lee L, Rao Panduranga S, Mathew Anna V, Hsu Chi-Yuan, Parsa Afshin, Vasan Ramachandran S, Kimmel Paul L, Clish Clary B, Coresh Josef, Feldman Harold I, Grams Morgan E

Abstract excerpt

Metabolomics genome wide association study (GWAS) help outline the genetic contribution to human metabolism. However, studies to date have focused on relatively healthy, population-based samples of White individuals. Here, we conducted a GWAS of 537 blood metabolites measured in the Chronic Renal Insufficiency Cohort (CRIC) Study, with separate analyses in 822 White and 687 Black study participants. Trans-ethnic...

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Identifiers

PMID: 35120996
DOI: 10.1016/j.kint.2022.01.014
PMCID: PMC8940669

Genes

ACOT2
FAAH
FADS1
LIPC
PHYHD1
PYROXD2

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