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Article

Ancestry-driven metabolite variation provides insights into disease states in admixed populations.

Genome medicine - 17 Jul 2023

Reynolds Kaylia M, Horimoto Andrea R V R, Lin Bridget M, Zhang Ying, Kurniansyah Nuzulul, Yu Bing, Boerwinkle Eric, Qi Qibin, Kaplan Robert, Daviglus Martha, Hou Lifang, Zhou Laura Y, Cai Jianwen, Shaikh Saame Raza, Sofer Tamar, Browning Sharon R, Franceschini Nora

Abstract excerpt

BACKGROUND: Metabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental factors. Hispanics/Latino individuals have ancestry-derived genomic regions (local ancestry) from their recent admixture that have been less characterized for associations with metabolite abundance and disease risk. METHODS: We performed admixture mapping of 640...

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PMID: 37461045
DOI: 10.1186/s13073-023-01209-z
PMCID: PMC10351197

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ALMS1
FADS1
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LIPC

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