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Article

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies.

eLife - 4 Feb 2022

Rawle Daniel J, Le Thuy T, Dumenil Troy, Bishop Cameron, Yan Kexin, Nakayama Eri, Bird Phillip I, Suhrbier Andreas

Abstract excerpt

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/- mouse studies having informed our understanding of GZMA's physiological function. We show herein that Gzma-/- mice have a mixed C57BL/6J and C57BL/6N genetic background and retain the full-length nicotinamide nucleotide transhydrogenase (Nnt) gene, whereas Nnt is truncated in C57BL/6J mice. Chikungunya viral arthritis was...

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Identifiers

PMID: 35119362
DOI: 10.7554/eLife.70207
PMCID: PMC8816380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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