Article
A natural genetic variant of granzyme B confers lethality to a common viral infection.
PLoS pathogens - 1 Dec 2014
Andoniou Christopher E, Sutton Vivien R, Wikstrom Matthew E, Fleming Peter, Thia Kevin Y T, Matthews Antony Y, Kaiserman Dion, Schuster Iona S, Coudert Jerome D, Eldi Preethi, Chaudhri Geeta, Karupiah Gunasegaran, Bird Phillip I, Trapani Joseph A, Degli-Esposti Mariapia A
Abstract excerpt
Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susceptibility or resistance to pathogenic micro-organisms. While extensive polymorphism has been reported for the...
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