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Reassessing granzyme B: unveiling perforin-independent versatility in immune responses and therapeutic potentials

23 May 2024

Abstract excerpt

The pivotal role of Granzyme B (GzmB) in immune responses, initially tied to cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, has extended across diverse cell types and disease models. A number of studies have challenged conventional notions, revealing GzmB activity beyond apoptosis, impacting autoimmune diseases, inflammatory disorders, cancer, and neurotoxicity. Notably, the diverse functions of...

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PMID: 38846935
DOI: 10.3389/fimmu.2024.1392535

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