Article
Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
Cell research - 1 Nov 2011
Ma Wenbin, Ortiz-Quintero Blanca, Rangel Roberto, McKeller Morgan R, Herrera-Rodriguez Sara, Castillo Eliseo F, Schluns Kimberly S, Hall Mary, Zhang Huiyuan, Suh Woong-Kyung, Okada Hitoshi, Mak Tak W, Zhou Yang, Blackburn Michael R, Martinez-Valdez Hector
Abstract excerpt
Gene expression can be regulated by chromatin modifiers, transcription factors and proteins that modulate DNA architecture. Among the latter, AT-hook transcription factors have emerged as multifaceted regulators that can activate or repress broad A/T-rich gene networks. Thus, alterations of AT-hook genes could affect the transcription of multiple genes causing global cell dysfunction. Here we report that targeted...
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