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Macrophage migration inhibitory factor is overproduced through EGR1 in TET2low resting monocytes

3 Feb 2022

Abstract excerpt

Somatic mutation in TET2 gene is one of the most common clonal genetic events detected in age-related clonal hematopoiesis as well as in chronic myelomonocytic leukemia (CMML). In addition to being a pre-malignant state, TET2 mutated clones are associated with an increased risk of death from cardiovascular disease, which could involve cytokine/chemokine overproduction by monocytic cells. Here, we show in mice and...

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PMID: 35115654
DOI: 10.1038/s42003-022-03057-w

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