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Article

Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.

Structure (London, England : 1993) - 8 Sept 2010

Hoadley Kelly A, Xu Dongyi, Xue Yutong, Satyshur Kenneth A, Wang Weidong, Keck James L

Abstract excerpt

BLM, the protein product of the gene mutated in Bloom syndrome, is one of five human RecQ helicases. It functions to separate double Holliday junction DNA without genetic exchange as a component of the "dissolvasome," which also includes topoisomerase IIIα and the RMI (RecQ-mediated genome instability) subcomplex (RMI1 and RMI2). We describe the crystal structure of the RMI core complex, comprising RMI2 and the...

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Source

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Identifiers

PMID: 20826341
DOI: 10.1016/j.str.2010.06.009
PMCID: PMC2937010

Genes

BLM
RMI2
RMI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.PMID 20826341Read ↗

The BLM dissolvasome in DNA replication and repair.Semantic proximity Read ↗

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Semantic proximity Read ↗

A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.Semantic proximity Read ↗

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loopsSemantic proximity Read ↗

BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.Semantic proximity Read ↗

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome.Semantic proximity Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resectionSemantic proximity Read ↗

More complexity to the Bloom's syndrome complex.Semantic proximity Read ↗

The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.Semantic proximity Read ↗

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.Semantic proximity Read ↗

Aberrant chromosome morphology in human cells defective for Holliday junction resolution.Semantic proximity Read ↗

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