Article
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
eLife - 9 Apr 2013
Shimomura Kazuhiro, Kumar Vivek, Koike Nobuya, Kim Tae-Kyung, Chong Jason, Buhr Ethan D, Whiteley Andrew R, Low Sharon S, Omura Chiaki, Fenner Deborah, Owens Joseph R, Richards Marc, Yoo Seung-Hee, Hong Hee-Kyung, Vitaterna Martha H, Bass Joseph, Pletcher Mathew T, Wiltshire Tim, Hogenesch John, Lowrey Phillip L, Takahashi Joseph S
Abstract excerpt
Genetic and molecular approaches have been critical for elucidating the mechanism of the mammalian circadian clock. Here, we demonstrate that the ClockΔ19 mutant behavioral phenotype is significantly modified by mouse strain genetic background. We map a suppressor of the ClockΔ19 mutation to a ∼9...
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