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Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

2 Feb 2022

Abstract excerpt

Abstract Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and intervertebral disc disorder (IDD) (58,854 cases, 922,958 controls). We identify 41 variants at 33 loci. The most significant association (OR IDD = 0.92, P = 1.6 ×...

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PMID: 35110524
DOI: 10.1038/s41467-022-28167-1

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