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Article

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations.

Nature communications - 7 Nov 2024

Salo Ville, Määttä Juhani, Sliz Eeva, Reimann Ene, Mägi Reedik, Reis Kadri, Elhanas Abdelrahman G, Reigo Anu, Palta Priit, Esko Tõnu, Karppinen Jaro, Kettunen Johannes

Abstract excerpt

Given that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs, the genetic basis of LDH has received relatively little research. Our aim is to increase understanding of the genetic factors influencing LDH. We perform a genome-wide association analysis (GWAS) of LDH in the FinnGen project and in Estonian and UK biobanks, followed by a...

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Identifiers

PMID: 39511132
DOI: 10.1038/s41467-024-53467-z
PMCID: PMC11544010

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