Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.

doi:10.1371/journal.pgen.1007601

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Article

Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.

PLoS genetics - 1 Sept 2018

Suri Pradeep, Palmer Melody R, Tsepilov Yakov A, Freidin Maxim B, Boer Cindy G, Yau Michelle S, Evans Daniel S, Gelemanovic Andrea, Bartz Traci M, Nethander Maria, Arbeeva Liubov, Karssen Lennart, Neogi Tuhina, Campbell Archie, Mellstrom Dan, Ohlsson Claes, Marshall Lynn M, Orwoll Eric, Uitterlinden Andre, Rotter Jerome I, Lauc Gordan, Psaty Bruce M, Karlsson Magnus K, Lane Nancy E, Jarvik Gail P, Polasek Ozren, Hochberg Marc, Jordan Joanne M, Van Meurs Joyce B J, Jackson Rebecca, Nielson Carrie M, Mitchell Braxton D, Smith Blair H, Hayward Caroline, Smith Nicholas L, Aulchenko Yurii S, Williams Frances M K

Abstract excerpt

Back pain is the #1 cause of years lived with disability worldwide, yet surprisingly little is known regarding the biology underlying this symptom. We conducted a genome-wide association study (GWAS) meta-analysis of chronic back pain (CBP). Adults of European ancestry were included from 15 cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and from the UK Biobank...

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PMID: 30261039
DOI: 10.1371/journal.pgen.1007601
PMCID: PMC6159857

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