Article
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.
The Journal of clinical investigation - 1 Nov 2013
Song You-Qiang, Karasugi Tatsuki, Cheung Kenneth M C, Chiba Kazuhiro, Ho Daniel W H, Miyake Atsushi, Kao Patrick Y P, Sze Kit Ling, Yee Anita, Takahashi Atsushi, Kawaguchi Yoshiharu, Mikami Yasuo, Matsumoto Morio, Togawa Daisuke, Kanayama Masahiro, Shi Dongquan, Dai Jin, Jiang Qing, Wu Chengai, Tian Wei, Wang Na, Leong John C Y, Luk Keith D K, Yip Shea-ping, Cherny Stacey S, Wang Junwen, Mundlos Stefan, Kelempisioti Anthi, Eskola Pasi J, Männikkö Minna, Mäkelä Pirkka, Karppinen Jaro, Järvelin Marjo-Riitta, O'Reilly Paul F, Kubo Michiaki, Kimura Tomoatsu, Kubo Toshikazu, Toyama Yoshiaki, Mizuta Hiroshi, Cheah Kathryn S E, Tsunoda Tatsuhiko, Sham Pak-Chung, Ikegawa Shiro, Chan Danny
Abstract excerpt
Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people worldwide. A hallmark of LDD is loss of proteoglycan and water content in the nucleus pulposus of intervertebral discs. While some genetic determinants have been reported, the etiology of LDD is largely unknown. Here we report the findings from linkage and association studies on a total of 32,642...
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